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We're going to try the least risky drug first, so therefore opioids [ are ] not a first line of treatment in most cases, it's not a second line of treatment, and maybe not a third line of treatment.
A problematic interpretation of [ the study findings ] would be : Opioids don't provide any meaningful pain relief, the challenge with that interpretation is it assumes that every patient will get the same amount of pain relief.
It's a very complicated and diverse population of patients.
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