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Paul Northcott was the one of the first recipients of the AACR NextGen grant for transformative cancer research, a grant mechanism intended to support creative cancer research that may not be funded through conventional channels. Northcott’s research studies the molecular and genetic level of a type of childhood brain cancer called medulloblastoma, the most common malignant brain tumor in children, with five-year survival rates ranging from 30 to 80 percent. Through Paul Northcott research, Paul Northcott discovered molecular subgroups of medulloblastoma with distinct patient features, outcomes and mutational patterns. These findings changed the way the disease is studied, diagnosed and the way patients are treated, Paul Northcott said. There are no clinical compounds or FDA-approved drugs so I think the biggest challenge over the next several years is to take that information that we've gleaned from the genomics era and actually translate that into better treatment options for patients.
Found on FOX News 6 years ago
Paul Northcott said. Grants for early investigators like Paul Northcott may also help them obtain bigger funding opportunities through the National Institutes of Health( National Institutes of Health). We're able to recruit, we're able to conduct studies that we wouldn't have been able to otherwise. This then helps us build the necessary foundation to go after National Institutes of Health funding and getting that first RO1 through the NCI( National Cancer Institute), Paul Northcott said. One of the toughest hurdles for young investigators is securing their first R01, the gold standard of grants that give scientists enough money and time to complete a project and publish results within four or five years. The budget for R01’s is unlimited. According to the director of the National Cancer Institute, Dr. Norman Sharpless, the NCI is directing their extramural funders to set aside additional funding to increase the total number of first R01's given to early-stage investigators by at least 25 percent in 2018. By training more diverse groups of scientists, organizations like the National Cancer Institute hope to spur new commitments to basic science that can drive novel approaches and technologies to cancer treatment. Paul Northcott says supporting the next generation of cancer scientists is crucial to ensuring a talented and creative research workforce for the decades ahead. Oftentimes it’s difficult to see how studying a single gene or a pathway or a biochemical mechanism might have a broader impact, but I would encourage anyone involved and anyone starting out in this type of field to think about what is the goal of Cancer Research -LRB- AACR -RRB- ? How can this research change health care, or, in this case, cancer research ?
Found on FOX News 6 years ago
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