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Some of them may have been rapidly domesticated by humans simply moving them or transporting them [along trade routes such as the silk road] from the Caucasus all the way to East Asia, so, its possible that humans were stillinflicting evolutionary changeson these plants without actually intensively cultivating them.
Our study implies that knowledge of cannabis smoking and specific high-chemical-producing varieties of the cannabis plant were among the cultural traditions that spread along these exchange routes, modern perspectives on cannabis vary tremendously cross-culturally, but it is clear that the plant has a long history of human use, medicinally, ritually, and recreationally, over countless millennia.
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