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The particular question is, what was responsible? Actually what pathogen, what bacteria formed the Great Plague outbreak in the 17th century? it doesn't seem to come back, so something changed in the way people were living. People say the Great Fire of London in 1666 had something to do with the ending of Great Plague events, but through the scientific studies we can do these days on DNA from samples of these skeletons, we might be able to tell what pathogen is responsible for that outbreak and perhaps why it stopped.