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Treatments work best when given prior to symptoms starting or at the very start of symptom onset. This is something not possible with sporadic ALS because it takes time to establish a diagnosis, and by then, the symptoms can be quite advanced, while this treatment would only affect 2% of ALS patients, it may be much more impactful than other treatments for ALS, since it can be administered much earlier in the disease process -- perhaps even before a patient develops symptoms.