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Our hypothesis is that in a diseased state, your brain is going to have higher energy hills and lower energy valleys. More so than a placebo, different parts of their brain can’t talk to each other, that’s why someone stuck in a negative pattern of thought could be having a hard time — in spite of new evidence they’re not able to see that there are reasons to be happy. Psychedelic therapy could flatten out that energy landscape again and allow more information to come in. It could allow depressed or anxious people to update their models of the world.