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Horse dung is a very rich substrate that harbours a diversity of micro-organisms, including fungi and bacteria, now these micro-organisms are in a constant competition for nutrients and space and it's therefore very likely to find potent antibiotics in such an environment, which are used by the different organisms to inhibit the growth of the competitors.
Now copsin kills bacteria by binding to an essential cell wall building block, the cell wall you can consider like the achilles heel of bacteria, so when you disrupt the cell wall synthesis bacteria usually dies rapidly. The binding pattern of copsin on this building block is very unique and therefore copsin is active against bacteria resistant to conventional antibiotics.
Copsin is an exceptionally stable protein, so you can for example boil it at 100 degrees, you can put it in strong acid for hours, you can also treat it with very aggressive enzymes and it remains completely active. This feature allows us, for example, also to go into applications in food industry, food preservation, productions where strong acids in high temperatures are very common.
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